Strychnogucines A and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos icaja
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چکیده
منابع مشابه
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more activ...
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In considération of thé many biological properties of alkaloids, and particularly of quinine (which remains an important antimalarial drug), it was not surprising that a séries of indolomonoterpenic alkaloids, mainly isolated from Strychnos usambarensis Gilg and from Strychnos icaja Baill., thé latter used in traditional medicine from Central Africa to treat chronic malaria, présent antiplasmod...
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ژورنال
عنوان ژورنال: Journal of Natural Products
سال: 2000
ISSN: 0163-3864,1520-6025
DOI: 10.1021/np000285t